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Larissa  is the capital and biggest city of the Thessaly region of Greece and capital of the Larissa regional unit. It is a principal agricultural centre and a national transportation hub, linked by road and rail with the port of Volos, the city of Thessaloniki and Athens. Larissa, within its municipality, has 162,591 inhabitants, while the regional unit of Larissa reached a population of 284,325 (in 2011).

The urban area of the city, although mostly contained within the Larissa municipality, also includes the communities of Giannouli, Platykampos, Nikaia, Terpsithea and several other suburban settlements, bringing the wider urban area population of the city to about 220,000 inhabitants. Today, Larissa is a major commercial and industrial centre in Greece. Legend has it that Achilles was born here, and that Hippocrates, the Father of Medicine, died here.